Base-Free Iridium-Catalyzed Hydrogenation of Esters and Lactones
journal contributionposted on 15.04.2016, 13:53 by Timothy P. Brewster, Nomaan M. Rezayee, Zuzana Culakova, Melanie S. Sanford, Karen I. Goldberg
Half-sandwich iridium bipyridine complexes catalyze the hydrogenation of esters and lactones under base-free conditions. The reactions proceed with a variety of ester and lactone substrates. Mechanistic studies implicate a pathway involving rate-limiting hydride transfer to the substrate at high pressures of H2 (≥50 bar).