jo052194c_si_002.pdf (270.37 kB)
Base−Base Interactions in the Minor Groove of Double-Stranded DNA
journal contribution
posted on 2006-07-21, 00:00 authored by Tongfei Wu, Koen Nauwelaerts, Arthur Van Aerschot, Matheus Froeyen, Eveline Lescrinier, Piet HerdewijnA method has been developed for the synthesis of bisheaded nucleosides with thymine and adenine base
moieties. We have demonstrated that, when incorporated in oligonucleotides, extrahelical A−T base
interactions are possible when the bisheaded nucleosides are positioned in opposite strands of the duplex
and are separated from each other by one regular base pair.