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Base-Promoted Nitrile–Alkyne Domino-Type Cyclization: A General Method to Trisubstituted Imidazoles

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journal contribution
posted on 09.12.2019, 21:12 by Qiang Wang, Xi Chen, Xin-Gang Wang, Hong-Chao Liu, Yong-Min Liang
An efficient base promoted nitrile-alkyne domino-type cyclization for multicomponent assembly of imidazoles from alkynes, nitriles, and tBuOK has been developed, which could run even in the absence of solvent on a gram scale with complete atom economy. This method contributes directly to reaching the synthesis of valuable imidazole derivatives from readily available raw materials.