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Base-Mediated One-pot Synthesis of Oxygen-Based Heterocycles from 2‑Hydroxyphenyl-Substituted para-Quinone Methides

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journal contribution
posted on 09.12.2019, 18:59 by Gurdeep Singh, Suresh Kumar, Arjun Chowdhury, Ramasamy Vijaya Anand
One-pot synthesis of oxygen-containing heterocycles has been achieved through alkylation/acylation of 2-hydroxyphenyl-substituted para-quinone methides followed by an intramolecular 1,6-conjugate addition/cyclization and oxidation sequence. This protocol provides access to a wide range of oxygen-based heterocycles, such as 2,3-disubstituted benzo­[b]­furans, 2,3-dihydrobenzofurans and diaryl-substituted coumarin derivatives in moderate to good yields.