posted on 2020-09-29, 13:34authored byYong Chen, Hai-Lun Wan, Yuan Huang, Song Liu, Feiyi Wang, Cuifen Lu, Junqi Nie, Zuxing Chen, Guichun Yang, Chao Ma
We report herein a B(C6F5)3-catalyzed
redox-neutral β-functionalization of pyrrolidines with isatins.
Under transition-metal- and oxidant-free conditions at ambient temperature,
a series of pyrrolidines bearing a functionalized exocyclic alkene
are accessed in high efficiency through a borrowing hydrogen process.
A simple switch to higher reaction temperature in a one-pot procedure
also provides access to a diverse array of C(3)-functionalized pyrroles
while liberating water and hydrogen gas as the only byproducts.