Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola

Wu, Quan-Xiang; Crews, Mitchell S.; Draskovic, Marija; Sohn, Johann; Johnson, Tyler A.; Tenney, Karen; Valeriote, Frederick A.; Yao, Xiao-Jun; Bjeldanes, Leonard F.; Crews, Phillip

doi:10.1021/ol101396n.s001

ol101396n_si_001.pdf (5.52 MB)

Azonazine, a Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus insulicola

journal contribution

posted on 2010-10-15, 00:00 authored by Quan-Xiang Wu, Mitchell S. Crews, Marija Draskovic, Johann Sohn, Tyler A. Johnson, Karen Tenney, Frederick A. Valeriote, Xiao-Jun Yao, Leonard F. Bjeldanes, Phillip Crews

Azonazine, a unique hexacyclic dipeptide, was isolated from a Hawaiian marine sediment-derived fungus eventually identified as Aspergillus insulicola. Its absolute configuration, 2R,10R,11S,19R, was established using NMR, HRESIMS, and CD data plus insights derived from molecular models. A possible route for its biogenesis is proposed, and biological properties were explored against cancer cell lines and in an NFκB inhibition assay.