Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411
journal contributionposted on 31.01.2019, 00:00 by Jia-Lin Tang, Zong-Yuan Zhou, Tao Yang, Can Yao, Lin-Wei Wu, Guo-You Li
Nine new azaphilone alkaloids, penazaphilones A–I (1–9), were isolated from the solid fermented rice culture of Penicillium sclerotiorum cib-411. The structures of compounds 1–9 were elucidated based on HRESIMS, NMR, and CD spectroscopic data. The structures of 5 and 8 were confirmed by X-ray crystallographic analyses. Biological evaluation showed that compounds 1, 5, 6, and 8 inhibited the production of nitric oxide (NO) on RAW 264.7 cells stimulated by lipopolysaccharide with IC50 values of 15.29, 9.34, 9.50, and 7.05 μM, respectively. Meanwhile, they did not exhibit obvious cytotoxicity at a concentration of 50.0 μM.
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exhibitFungus Penicillium sclerotiorum cib -411nitric oxideconcentrationPenicillium sclerotiorum cib -411.azaphilone alkaloids7.05 μ Mrice cultureIC 50 valuesAnti-inflammatory ActivityX-ray50.0 μ Mcompounds 1penazaphiloneBiological evaluationanalysesRAW 264.7 cellsAzaphilone AlkaloidscytotoxicitylipopolysaccharideNMRHRESIMSCD spectroscopic data