American Chemical Society
ol6b01159_si_001.pdf (5.43 MB)

Axial Chirality about Boron–Carbon Bond: Atropisomeric Azaborines

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journal contribution
posted on 2016-05-20, 17:33 authored by Andrea Mazzanti, Elia Mercanti, Michele Mancinelli
The preparation of atropisomeric 2,1-borazaro­naph­thalenes is described. Resolution of the atropisomeric pair was achieved by preparative Chiral Stationary Phase HPLC (CSP-HPLC). The absolute configuration of the stereogenic axis was derived from Time-Dependent DFT (TD-DFT) simulation of the Electronic Circular Dichroism spectra (ECD). X-ray diffraction and Dynamic NMR data allowed structural and dynamic comparison with the analogue isosteric carbon compounds.