Auxiliary-Assisted Palladium-Catalyzed Direct C(sp³)–H Sulfonamidation To Afford 1,2-Amino Alcohol Derivatives

An auxiliary-assisted Pd-catalyzed C­(sp³)–H sulfonamidation approach using NFSI as both nitrogen source and oxidant to afford 1,2-amino alcohol derivatives is described in this paper. This method is novel and attractive because of its high yields, wide range of substrate scopes, and good tolerance for many functional groups. Oximido and sulfonyl group can be removed with this method.