posted on 2019-08-01, 18:43authored byTingting Zhang, Yue Xing, Yu Song, Yue Gu, Xiaoyi Yan, Nannan Lu, He Liu, Zhiqian Xu, Haixin Xu, Zhiquan Zhang, Ming Yang
Here,
we report ZIF-8-reduced graphene oxide (ZIF-8–rGO)-supported
bimetallic AuPt nanoparticles (AuPtNPs) as a novel peroxidase mimic
for high-sensitivity detection of H2O2 in neutral
solution. ZIF-8–graphene oxide (ZIF-8–GO) is first synthesized
via a simple wet-chemistry process and subsequently immobilized with
AuPtNPs via a reduction method. The resultant AuPt/ZIF-8–rGO
shows enhanced peroxidase-like catalytic activity and it is applied
for the electrochemical detection of H2O2 in
a wide concentration range, from 100 nM to 18 mM, with a very low
detection limit of 19 nM (S/N = 3). This good electroanalytical performance
of AuPt/ZIF-8–rGO is owing to the ultrasmall size and high
dispersion of the AuPtNPs, the strong metal–support interaction
between the AuPtNPs and ZIF-8–rGO bisupport, and the sandwich-like
structure comprising porous ZIF-8 and loosely packed rGO nanosheets.
The AuPt/ZIF-8–rGO is employed for the practical detection
of H2O2 in human serum samples with desirable
properties. Therefore, the novel AuPt/ZIF-8–rGO is a promising
nanozyme for various biotechnological and environmental applications.