Atmospheric Pressure Drift Tube Ion Mobility–Orbitrap Mass Spectrometry: Initial Performance Characterization
journal contributionposted on 11.10.2017, 00:00 by Joel D. Keelor, Stephen Zambrzycki, Anyin Li, Brian H. Clowers, Facundo M. Fernández
Atmospheric pressure drift tube ion mobility spectrometry (AP-DTIMS) was coupled with Fourier transform Orbitrap mass spectrometry. The performance capabilities of this versatile new arrangement were demonstrated for different DTIMS ion gating operation modes and Orbitrap mass spectrometer parameters with regard to sensitivity and resolving power. Showcasing the optimized AP-DTIMS-Orbitrap MS system, isobaric peptide and sugar isomers were successfully resolved and the identities of separated species validated by high-energy collision dissociation experiments.
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TubespeciescapabilityFourierIonOrbitrap mass spectrometer parametersDriftarrangementsensitivityisobaric peptideregardInitial Performance Characterization Atmospheric pressure drift tube ion mobility spectrometryShowcasingSpectrometryDTIMS ion gating operation modescollision dissociation experimentsoptimized AP-DTIMS-Orbitrap MS systemMobilityOrbitrap mass spectrometrysugar isomersidentityperformance capabilities