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Download fileAsymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel
journal contribution
posted on 2020-01-15, 17:37 authored by Siyu Guo, Xiuhua Wang, Jianrong Steve ZhouNickel-catalyzed
asymmetric hydrogenation of several types of alkenes
proceeds in high enantioselectivity, using acetic acid or water as
the hydrogen source and indium powder as electron donor. The scope
of alkenes herein include α,β-unsaturated esters, nitriles, and ketones
as well as allylic alcohols. Asymmetric deuteration of α,β-unsaturated
esters is also achieved with deuterated water, the cheapest deuterium
source.