ol0c01213_si_001.pdf (29.03 MB)
Asymmetric Transfer Hydrogenation of o‑Hydroxyphenyl Ketones: Utilizing Directing Effects That Optimize the Asymmetric Synthesis of Challenging Alcohols
journal contribution
posted on 2020-04-16, 19:46 authored by Ye Zheng, Guy J. Clarkson, Martin WillsA systematic
range of o-hydroxyphenyl ketones
were reduced under asymmetric transfer hydrogenation conditions using
the C3-tethered catalyst 2. Two directing effects, i.e.,
an o-hydroxyphenyl coupled to a bulky aromatic on
the opposite side of the ketone substrate, combine in a matched manner
to deliver reduction products with very high enantiomeric excess.