ol9b00059_si_001.pdf (1.44 MB)
Asymmetric Transfer Hydrogenation of Heterobicyclic Alkenes with Water as Hydrogen Source
journal contribution
posted on 2019-02-12, 14:50 authored by Guoli Shen, Jingchao Chen, Dandan Xu, Xia Zhang, Yongyun Zhou, Baomin FanThe
asymmetric transfer hydrogenation of heterobicyclic alkenes
was accomplished by using water as the sole hydrogen source. The transformation
was co-catalyzed by Pd(OAc)2/Zn(OTf)2 dual catalyst
with metallic zinc as reducing agent. Various azabenzonorbornadienes
and oxabenzonorbornadienes were transformed to the corresponding chiral
1,2-dihydronaphthalenes by the asymmetric reductive ring-opening reactions
with good to excellent enantioselectivities.