Asymmetric Transfer Hydrogenation of Aryl Ketones Catalyzed by Salt-Free Two Samarium Centers Supported by a Chiral Multidentate Alkoxy Ligand
journal contributionposted on 09.12.2004, 00:00 by Kouji Ohno, Yasutaka Kataoka, Kazushi Mashima
We synthesized a chiral multidentate ligand, (R,R,R,R)-N,N,N‘,N‘-tetra(2-hydroxy-2-phenylethyl)-1,3-xylylene diamine [(R)-2], which can support two metals at adjacent positions. Asymmetric transfer hydrogenation of acetophenone and its derivatives was conducted by using salt-free bimetallic lanthanoid complexes of (R)-2, and the combination of two samarium atoms and (R)-2 was found to be the best catalyst system for asymmetric transfer hydrogenation of aryl ketones in high enantioselectivity (up to >99% ee).
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enantioselectivitydiamineAsymmetric transfer hydrogenationderivativesamarium atomscomplexeearyl ketoneslanthanoidbimetalliccombinationchiral multidentate ligandAsymmetric Transfer HydrogenationSamarium CentersAryl Ketones Catalyzedcatalyst systemtetratransfer hydrogenationChiral Multidentate Alkoxy Ligandacetophenone