American Chemical Society
jo7b01502_si_001.pdf (2.8 MB)

Asymmetric Total Synthesis of Nannocystin A

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journal contribution
posted on 2017-08-08, 00:00 authored by Qiang Liu, Ping Hu, Yun He
Nannocystin A is a novel 21-membered macrolactone isolated from myxobacterium Nanocystis sp. It is a potent elongation factor 1 inhibitor and inhibits cancer cell line growth at nanomolar concentrations. In this work, a concise asymmetric total synthesis of nannocystin A has been developed, which features Sharpless epoxidation, Stille coupling, and final macrolactamization.