Asymmetric Total Synthesis of Nannocystin A
journal contributionposted on 08.08.2017, 00:00 authored by Qiang Liu, Ping Hu, Yun He
Nannocystin A is a novel 21-membered macrolactone isolated from myxobacterium Nanocystis sp. It is a potent elongation factor 1 inhibitor and inhibits cancer cell line growth at nanomolar concentrations. In this work, a concise asymmetric total synthesis of nannocystin A has been developed, which features Sharpless epoxidation, Stille coupling, and final macrolactamization.