posted on 2017-08-08, 00:00authored byQiang Liu, Ping Hu, Yun He
Nannocystin
A is a novel 21-membered macrolactone isolated from myxobacterium Nanocystis sp. It is a potent elongation factor 1 inhibitor
and inhibits cancer cell line growth at nanomolar concentrations.
In this work, a concise asymmetric total synthesis of nannocystin
A has been developed, which features Sharpless epoxidation, Stille
coupling, and final macrolactamization.