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Asymmetric Total Synthesis of Fawcettimine-Type Lycopodium Alkaloid, Lycopoclavamine‑A

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journal contribution
posted on 28.03.2019, 00:00 by Hiroki Kaneko, Shunsuke Takahashi, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama
An asymmetric total synthesis of lycopoclavamine-A (1), a structurally unique fawcettimine-type Lycopodium alkaloid, was achieved via a stereoselective Pauson–Khand reaction and a stereoselective conjugate addition to construct a quaternary carbon center at C-12.

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