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Asymmetric Synthesis of the Four Possible Fagomine Isomers

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journal contribution
posted on 2003-04-02, 00:00 authored by Hiroki Takahata, Yasunori Banba, Hidekazu Ouchi, Hideo Nemoto, Atsushi Kato, Isao Adachi
The asymmetric synthesis of fagomine and its congeners 14 has been achieved by catalytic ring-closing metathesis (RCM). The synthesis involved the construction of the piperidene-type chiral building block 5 followed by dihydroxylation, starting from the d-serine-derived Garner aldehyde 6.

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