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Asymmetric Synthesis of syn-α-Substituted β-Amino Ketones by Using Sulfinimines and Prochiral Weinreb Amide Enolates

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journal contribution
posted on 07.06.2007, 00:00 by Franklin A. Davis, Minsoo Song
syn-α-Substituted β-amino Weinreb amides are new chiral building blocks for asymmetric synthesis of syn-α-substituted β-amino acids, aldehydes, and ketones and are prepared by addition of prochiral lithium enolates of Weinreb amides to sulfinimines (N-sulfinyl imines).