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Asymmetric Synthesis of Polyfunctionalized Pyrrolidines from Sulfinimine-Derived Pyrrolidine 2-Phosphonates. Synthesis of Pyrrolidine 225C

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journal contribution
posted on 2006-05-25, 00:00 authored by Franklin A. Davis, He Xu, Yongzhong Wu, Junyi Zhang
The Horner−Wadsworth−Emmons reaction of aldehydes with sulfinimine-derived 3-oxo pyrrolidine phosphonates represents a new method for the asymmetric synthesis of ring-functionalized cis-2,5-disubstituted 3-oxo pyrrolidines.

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