Asymmetric Synthesis of Differentially Protected 2,7-Diaminosuberic Acid, a Ring-Closure Metathesis Approach

An efficient and versatile method has been developed for the synthesis of a selectively protected 2,7-diaminosuberic acid derivative. A Grubbs ring-closure olefin metathesis reaction was used as a key step on an allylglycine-derived template.