jo048903o_si_002.pdf (27.27 kB)
Asymmetric Synthesis of C-Aliphatic Homoallylic Amines and Biologically Important Cyclohexenylamine Analogues
journal contributionposted on 2004-10-29, 00:00 authored by Chi-Lik Ken Lee, Hui Yvonne Ling, Teck-Peng Loh
An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.