American Chemical Society
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Asymmetric Synthesis of C-Aliphatic Homoallylic Amines and Biologically Important Cyclohexenylamine Analogues

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journal contribution
posted on 2004-10-29, 00:00 authored by Chi-Lik Ken Lee, Hui Yvonne Ling, Teck-Peng Loh
An efficient method for the asymmetric synthesis of C-aliphatic homoallylic amines with up to 94% yield and 80% de is reported. Ring-closing metathesis of several chiral homoallylic amines using the second-generation Grubbs catalyst provided easy access to a wide variety of cyclohexenylamines.