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Asymmetric Sulfur Ylide Mediated Aziridination:  Application in the Synthesis of the Side Chain of Taxol

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journal contribution
posted on 24.09.2003, 00:00 authored by Varinder K. Aggarwal, Jean-Luc Vasse
Sulfur ylide methodology has been used to construct the Taxol side chain with a high degree of enantioselectivity via a trans-aziridine followed by stereospecific rearrangement of the trans-benzoylaziridine into a trans-oxazoline.