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Asymmetric Pericyclic Cascade Approach to Spirocyclic Oxindoles

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journal contribution
posted on 01.06.2012, 00:00 by Edward Richmond, Nicolas Duguet, Alexandra M. Z. Slawin, Tomáš Lébl, Andrew D. Smith
The reaction of chiral N-arylnitrones with carbocyclic alkylarylketenes generates spirocyclic oxindoles in good yields and with excellent levels of enantioselectivity (90–99% ee) via a pericyclic cascade process.