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Asymmetric Epoxidation of Olefins Catalyzed by Chiral Iminium Salts Generated in Situ from Amines and Aldehydes

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journal contribution
posted on 18.07.2001, 00:00 authored by Man-Kin Wong, Lai-Mei Ho, Yan-Song Zheng, Chun-Yu Ho, Dan Yang
A new approach for catalytic asymmetric epoxidation of olefins was developed that utilized chiral iminium salts, generated in situ from chiral amines and aldehydes, as catalysts. Epoxidation reactions can be conducted with 20 mol % of amines and aldehydes. The enantioselectivity of epoxides can be up to 65%. This modular approach obviates the difficulties inherent in the preparation and isolation of unstable exocyclic iminium salts.