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Asymmetric Epoxidation Catalyzed by α,α-Dimethylmorpholinone Ketone. Methyl Group Effect on Spiro and Planar Transition States

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journal contribution
posted on 21.08.2009, 00:00 by O. Andrea Wong, Bin Wang, Mei-Xin Zhao, Yian Shi
Asymmetric epoxidation of olefins by using an α,α-dimethylmorpholinone-containing chiral ketone catalyst (4) has been investigated. This ketone, which has the combined features of several previously studied catalysts, is an effective catalyst for trans- and trisubstituted olefins, and up to 97% ee has been achieved. The α,α-dimethyl group has significant impact on spiro and planar transition states.