posted on 2017-05-04, 00:00authored byDinghai Wang, Lianqian Wu, Fei Wang, Xiaolong Wan, Pinhong Chen, Zhenyang Lin, Guosheng Liu
We
have developed a copper-catalyzed enantioselective intermolecular
aminoarylation of alkenes using a novel N-fluoro-N-alkylsulfonamide as the amine reagent, which
could react with the Cu(I) catalyst to release a related amino radical.
After addition to styrene, the generated benzylic radical could couple
with a chiral L*CuIIAr complex to achieve
enantioselective arylation. Various optical 2,2-diarylethylamines
were efficiently synthesized from simple styrenes with high enantioselectivity,
and these products can serve as valuable synthons toward bioactive
molecules’ synthesis.