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Asymmetric Alkynylation of Aldehydes Catalyzed by an In(III)/BINOL Complex

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journal contribution
posted on 12.10.2005, 00:00 by Ryo Takita, Kenichiro Yakura, Takashi Ohshima, Masakatsu Shibasaki
Asymmetric alkynylation of both aromatic and aliphatic aldehydes using catalytic amounts of In(III)/BINOL is described. Dual activation of both substrates due to the “bifunctional character” of the indium(III) catalyst enables a broad range of substrate generality with high enantioselectivity (83 to >99% ee).