ol8b01584_si_001.pdf (8.44 MB)

Asymmetric [4 + 2]-Cycloaddition of Copper–Allenylidenes with Hexahydro-1,3,5-triazines: Access to Chiral Tetrahydroquinazolines

Download (8.44 MB)
journal contribution
posted on 06.06.2018, 20:31 by Danqing Ji, Cheng Wang, Jiangtao Sun
A copper-catalyzed asymmetric formal [4 + 2]-cycloaddition of copper–allenylidenes and hexahydro-1,3,5-triazines has been developed, providing chiral tetrahydroquinazolines in moderate to good yields and with high enantioselectivities for most cases (up to 88% yield and 98% ee).