American Chemical Society
np7b00397_si_001.pdf (2.86 MB)

Assignment of the Absolute Configuration of Phosphoeleganin via Synthesis of Model Compounds

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journal contribution
posted on 2017-07-12, 14:39 authored by Paolo Luciano, Concetta Imperatore, Maria Senese, Anna Aiello, Marcello Casertano, Yue-W. Guo, Marialuisa Menna
The full absolute configuration assignment of phosphoeleganin (1), a recently discovered marine-derived phosphorylated polyketide with protein tyrosine phosphatase 1B inhibitory activity, was achieved. It was based on the synthesis of model diasteroisomeric compounds of the C-8–C-12 segment portion of phosphoeleganin, chiral derivatization methods, and application of the universal NMR database concept.