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Aspirochlorine Class Compounds from Aspergillus flavus Inhibit Azole-Resistant Candida albicans

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journal contribution
posted on 26.08.2005, 00:00 by Paul Klausmeyer, Thomas G. McCloud, Kenneth D. Tucker, John H. Cardellina, Robert H. Shoemaker
Dereplication of the antifungal extracts of Aspergillus flavus indicated that the primary antifungal compound present was the known aspirochlorine (1). Preparative isolation work resulted in the identification of the new compounds tetrathioaspirochlorine (2) and cyclo(d-N-methyl-Leu-l-Trp) (3).