Asnovolins A–G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E
journal contributionposted on 14.09.2016, 12:34 by Kazuki Ishikawa, Fumiaki Sato, Takeshi Itabashi, Hiroshi Wachi, Hisashi Takeda, Daigo Wakana, Takashi Yaguchi, Ken-ichi Kawai, Tomoo Hosoe
Seven novel spiromeroterpenoids, asnovolins A–G (1–7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A–G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.