Asnovolins A–G, Spiromeroterpenoids Isolated
from the Fungus Aspergillus novofumigatus, and Suppression
of Fibronectin Expression by Asnovolin E

Ishikawa, Kazuki; Sato, Fumiaki; Itabashi, Takeshi; Wachi, Hiroshi; Takeda, Hisashi; Wakana, Daigo; Yaguchi, Takashi; Kawai, Ken-ichi; Hosoe, Tomoo

doi:10.1021/acs.jnatprod.6b00013.s001

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Asnovolins A–G, Spiromeroterpenoids Isolated from the Fungus Aspergillus novofumigatus, and Suppression of Fibronectin Expression by Asnovolin E

journal contribution

posted on 2016-09-14, 12:34 authored by Kazuki Ishikawa, Fumiaki Sato, Takeshi Itabashi, Hiroshi Wachi, Hisashi Takeda, Daigo Wakana, Takashi Yaguchi, Ken-ichi Kawai, Tomoo Hosoe

Seven novel spiromeroterpenoids, asnovolins A–G (1–7), one of which was shown to suppress fibronectin expression, were isolated from Aspergillus novofumigatus CBS117520 along with a known compound, novofumigatonin (8). The structures of asnovolins A–G were elucidated using MS and 2D-NMR data. Asnovolin E (5) suppressed fibronectin expression by normal human neonatal dermal fibroblast cells.