American Chemical Society
nl2c00819_si_001.pdf (1.04 MB)

Artificial Antigen Presenting Cells for Detection and Desensitization of Autoreactive T cells Associated with Type 1 Diabetes

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journal contribution
posted on 2022-05-26, 14:05 authored by Arbel Artzy-Schnirman, Enas Abu-Shah, Rona Chandrawati, Efrat Altman, Norkhairin Yusuf, Shih-Ting Wang, Jose Ramos, Catherine S. Hansel, Maya Haus-Cohen, Rony Dahan, Sefina Arif, Michael L. Dustin, Mark Peakman, Yoram Reiter, Molly M. Stevens
Autoimmune diseases and in particular type 1 diabetes rely heavily on treatments that target the symptoms rather than prevent the underlying disease. One of the barriers to better therapeutic strategies is the inability to detect and efficiently target rare autoreactive T-cell populations that are major drivers of these conditions. Here, we develop a unique artificial antigen-presenting cell (aAPC) system from biocompatible polymer particles that allows specific encapsulation of bioactive ingredients. Using our aAPC, we demonstrate that we are able to detect rare autoreactive CD4 populations in human patients, and using mouse models, we demonstrate that our particles are able to induce desensitization in the autoreactive population. This system provides a promising tool that can be used in the prevention of autoimmunity before disease onset.