American Chemical Society
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Aromatic ortho-Benzylation Reveals an Unexpected Reductant

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journal contribution
posted on 2008-11-06, 00:00 authored by Andrew Martins, Mark Lautens
The discovery of a novel arylpalladium(II) reduction enables the synthesis of diarylmethanes via reductive benzylation. Benzyl chlorides were found to be the major source of hydride, acting as an alkylating agent and an aprotic surrogate for benzyl alcohol. This represents the first example of an arylpalladium(II) reduction mediated by a benzyl halide.