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Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived Streptomyces sp.

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journal contribution
posted on 24.04.2015, 00:00 by Zeinab G. Khalil, Ritesh Raju, Andrew M. Piggott, Angela A. Salim, Antje Blumenthal, Robert J. Capon
Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 14, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 μM) and exhibited moderate and selective cytotoxicity against Gram-positive bacteria (IC50 >1.1 μM) and a panel of human cancer cell lines (IC50 > 7.5 μM). Significantly, 14 were cytotoxic (IC50 0.7–1.7 μM) against the Mycobacterium tuberculosis surrogate M. bovis bacille Calmette-Guérin.