Application of the Dötz Reaction to
Construction of a Major Portion of the
Ansa Macrocycle (−)-Kendomycin

White, James D.; Smits, Helmars

doi:10.1021/ol047779s.s001

Application of the Dötz Reaction to Construction of a Major Portion of the Ansa Macrocycle (−)-Kendomycin

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posted on 2005-01-20, 00:00 authored by James D. White, Helmars Smits

A Dötz reaction employing a terminal alkyne and a Fischer-type alkenylchromium carbenoid led to a pentasubstituted benzene from which a major portion of the Streptomyces metabolite (−)-kendomycin was synthesized.

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kendomycin Major Portion pentasubstituted benzene carbenoid D ötz reaction alkenylchromium application Construction Kendomycin Streptomyce Ansa metabolite terminal alkyne Macrocycle portion D ötz Reaction

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