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Application of High Pressure Induced by Water-Freezing to the Direct Catalytic Asymmetric Three-Component List−Barbas−Mannich Reaction

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journal contribution
posted on 21.08.2003, 00:00 authored by Yujiro Hayashi, Wataru Tsuboi, Mitsuru Shoji, Noriyuki Suzuki
High pressure induced by water-freezing has been successfully applied to the direct catalytic asymmetric-three component List−Barbas−Mannich reaction, in which higher yield and better enantioselectivity can be realized than those from the reaction at room temperature under 0.1 MPa.