np0706623_si_001.pdf (259.5 kB)

Aplysamine 6, an Alkaloidal Inhibitor of Isoprenylcysteine Carboxyl Methyltransferase from the Sponge Pseudoceratina sp.

Download (259.5 kB)
journal contribution
posted on 27.06.2008, 00:00 by Malcolm S. Buchanan, Anthony R. Carroll, Gregory A. Fechner, Anthony Boyle, Moana Simpson, Rama Addepalli, Vicky M. Avery, John N. A. Hooper, Tony Cheung, Huwei Chen, Ronald J. Quinn
The anticancer target isoprenylcysteine carboxyl methyltransferase (Icmt) was the focus of a natural product high-throughput screening campaign. The Australian marine sponge Pseudoceratina sp. yielded aplysamine 6, a new bromotyrosine derivative with an α,β-unsaturated amide linkage, as the bioactive constituent. Its structure was determined by 1D and 2D NMR spectroscopy.