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Antiproliferative Triterpenoid Saponins of Dodonaea viscosa from the Madagascar Dry Forest

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journal contribution
posted on 25.09.2009, 00:00 by Shugeng Cao, Peggy Brodie, Martin Callmander, Richard Randrianaivo, Jeremi Razafitsalama, Etienne Rakotobe, Vincent E. Rasamison, Karen TenDyke, Yongchun Shen, Edward M. Suh, David G. I. Kingston
Bioassay-guided fractionation of an EtOH extract obtained from the roots of the Madagascan plant Dodonaea viscosa led to the isolation of two new antiproliferative oleanane-type triterpenoid saponins, dodoneasides A and B (1 and 2). The structures of these two new compounds were elucidated using 1D and 2D NMR experiments and mass spectrometry. Compounds 1 and 2 showed antiproliferative activity against the A2780 human ovarian cancer cell line with IC50 values of 0.79 and 0.70 μM, respectively.