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Antiproliferative Activity of Natural Taiwaniaquinoids and Related Compounds

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journal contribution
posted on 25.01.2017, 16:37 by Juan J. Guardia, Rubén Tapia, Soumicha Mahdjour, Fernando Rodriguez-Serrano, Nuria Mut-Salud, Rachid Chahboun, Enrique Alvarez-Manzaneda
The in vitro antiproliferative activities of some taiwaniaquinoids and related compounds with functionalized A, B, or C rings against human breast (MCF-7), colon (T-84), and lung (A-549) tumor cell lines were assayed. The most potent compounds, 16, 27, and 36, were more effective than the naturally occurring taiwaniaquinones A (4) and F (5) in all three cell lines. The structure–activity relationship study of these new taiwaniaquinoids highlighted the correlation between the bromo substituent and the antiproliferative activity, especially in MCF-7 cells. These findings indicate that some of the taiwaniaquinoids might be useful as cytostatic agents against breast, colon, and lung cancer cell lines.