posted on 2021-03-05, 19:05authored byMamadou
A. Baldé, Emmy Tuenter, Mohamed S. Traoré, Laura Peeters, An Matheeussen, Paul Cos, Guy Caljon, Tom Vermeyen, Wouter Herrebout, Aliou M. Balde, Kenn Foubert, Luc Pieters
Phytochemical investigation of the n-BuOH extract
of the roots of Terminalia albida Sc. Elliot (Combretaceae)
led to the isolation and identification of 10 oleanane triterpenoids
(1–10), among which six new compounds,
i.e., albidanoside A (2), albidic acid A (4), albidinolic acid (5), albidienic acid (8), albidolic acid (9), and albidiolic acid (10), and two triterpenoid aglycones, i.e., albidic acid B (6) and albidic acid C (7), were isolated here for the
first time from a natural source, along with two known compounds.
The structures of these constituents were established by means of
1D and 2D NMR spectroscopy and ESI mass spectrometry. The isolated
compounds were evaluated for their antiplasmodial and antimicrobial
activity against the chloroquine-resistant strain Plasmodium
falciparum K1, Candida albicans, and Staphylococcus aureus. Compounds 1–4, 6, 7, and 8 showed
moderate antiplasmodial activity with IC50 values between
5 and 15 μM. None of the tested compounds were active against C. albicans or S. aureus. These findings
emphasize the potential of T. albida as a source
for discovery of new antiplasmodial compounds.