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Antimicrobial Silver Nanoclusters Bearing Biocompatible Phosphorylcholine-Based Zwitterionic Protection
journal contribution
posted on 2016-09-30, 00:00 authored by Arunee Sangsuwan, Hideya Kawasaki, Yoshinobu Matsumura, Yasuhiko IwasakiInfection
is one of the most serious issues in medical treatments
leading to the development of several antimicrobial agents. In particular,
silver ions released from silver substrates is well-known as a reliable
antimicrobial agent that either kills the microorganisms or inhibits
their growth. Unfortunately, many reports have shown that silver-based
antimicrobial agents are toxic for human cells as well. To improve
the biocompatibility of silver antimicrobial agents, we have synthesized
thiol-terminated phosphorylcholine (PC-SH)-protected silver nanoclusters
(PC–AgNCs) via strong thiol–metal coordination with
controlled ultrasmall size of the clusters. A change in plasmon-like
optical absorption was studied to affirm the successful synthesis
of small thiolated AgNCs through the absorption spectra that become
molecular-like for the AgNCs. We observed that PC–AgNCs were
spherical with an average diameter of <2 nm. The ultrasmall size
clusters were exceedingly immobilized by the PC-SH on the surface,
resulting in excellent biocompatibility and antibacterial activity
simultaneously. The biocompatible, antimicrobial PC–AgNCs exhibit
interesting advantages compared with other silver antimicrobial agents
for medical applications.
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antimicrobial agentsAntimicrobial Silver Nanoclusters Bearing Biocompatible Phosphorylcholine-Based Zwitterionic Protection Infectionultrasmall size clusterssilver-based antimicrobial agentsthiolated AgNCsantimicrobial agentPC-SHPCsilver ionsabsorption spectrathiol-terminated phosphorylcholineultrasmall sizesilver substratessilver antimicrobial agents
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