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Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity

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journal contribution
posted on 17.07.2017, 00:00 by Daniel E. Mitchell, Guy Clarkson, David J. Fox, Rebecca A. Vipond, Peter Scott, Matthew I. Gibson
Antifreeze proteins are produced by extremo­phile species to control ice formation and growth, and they have potential applications in many fields. There are few examples of synthetic materials which can reproduce their potent ice recrystallization inhibition property. We report that self-assembled enantiomerically pure, amphi­pathic metallo­helicies inhibited ice growth at just 20 μM. Structure–property relationships and calculations support the hypothesis that amphi­pathicity is the key motif for activity. This opens up a new field of metallo-organic antifreeze protein mimetics and provides insight into the origins of ice-growth inhibition.

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