Hemocompatibility
and antibacterial property are essential for
blood contact devices and medical intervention materials. In this
study, positively charged quaternary ammonium (QAC) and hydrophobic
benzyl group (OBzl) were introduced onto hydrophilic lysine methacrylamide
(LysAAm) to obtain two monomers LysAAm–QAC and LysAAm–OBzl,
respectively. The structure characterizations of LysAAm–QAC
and LysAAm–OBzl were determined by proton nuclear magnetic
resonance, Fourier transform infrared spectroscopy, and time-of-flight
secondary ion mass spectrometry. LysAAm–QAC and LysAAm–OBzl
were cografted onto a silicon wafer with different feeding ratios
to construct antifouling and antibacterial properties. The results
of fibrinogen adsorption and platelet adhesion proved that the modified
sample with the feeding ratio of 3:7 had superior antifouling property.
Furthermore, an antimicrobial test with both 2 and 24 h indicated
that the modified sample with the feeding ratio of 3:7 had antibacterial
ability. The antifouling property was provided by the high surface
coverage of LysAAm–QAC and LysAAm–OBzl (91.49%) and
the hydrophilic main structure LysAAm on LysAAm–QAC and LysAAm–OBzl
(water contact angle was 43.6°). The antibacterial property was
improved with the proportion of LysAAm–OBzl (43.6–58.5%)
because the increasing hydrophobic OBzl enhanced the ability to insert
into the membrane of bacteria and raise the bactericidal efficiency.
In application, LysAAm–QAC and LysAAm–OBzl with the
feeding ratio of 3:7 were grafted onto the surface of poly(styrene-b-(ethylene-co-butylene)-b-styrene), and a bifunctional surface with antifouling and antibacterial
properties was fabricated, which had promising applications in blood
contact devices and medical intervention materials.