Antibiotic Indole Sesquiterpene Alkaloid from Greenwayodendron suaveolens with a New Natural Product Framework
journal contributionposted on 28.05.2010, 00:00 by Russell B. Williams, Jin-Feng Hu, Krista M. Olson, Vanessa L. Norman, Matt G. Goering, Mark O’Neil-Johnson, Gary R. Eldridge, Courtney M. Starks
High-throughput natural products chemistry methods have led to the isolation of three new (1−3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structures were determined using CapNMR and MS. Pentacyclindole (1) was determined to possess a new natural product framework. Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC90 of 4 μg/mL.