posted on 2024-01-12, 17:07authored byRumiana Tenchov, Janet M. Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is typified
by a gradual loss of physiological fitness and
accumulation of cellular damage, leading to deteriorated functions
and enhanced vulnerability to diseases. Antiaging research has a long
history throughout civilization, with many efforts put forth to understand
and prevent the effects of aging. Multiple strategies aiming to promote
healthy aging and extend the lifespan have been developed including
lifestyle adjustments, medical treatments, and social programs. A
multitude of antiaging medicines and remedies have also been explored.
Here, we use data from the CAS Content Collection to analyze the publication
landscape of recent research related to antiaging strategies and treatments.
We review the recent advances and delineate trends in research headway
of antiaging knowledge and practice across time, geography, and development
pipelines. We further assess the state-of-the-art antiaging approaches
and explore their correlations with age-related diseases. The landscape
of antiaging drugs has been outlined and explored. Well-recognized
and novel, currently evaluated antiaging agents have also been summarized.
Finally, we review clinical applications of antiaging products with
their development pipelines. The objective of this review is to summarize
current knowledge on preventive strategies and treatment remedies
in the field of aging, to outline challenges and evaluate growth opportunities,
in order to further efforts to solve the problems that remain.