Anti-influenza Virus Polyketides from the Acid-Tolerant Fungus Penicillium purpurogenum JS03-21
journal contributionposted on 23.09.2011, 00:00 by Hui Wang, Yi Wang, Wei Wang, Peng Fu, Peipei Liu, Weiming Zhu
Fractionation of the ethyl acetate extract of an acid-tolerant fungus, Penicillium purpurogenum JS03-21, resulted in the isolation of six new compounds, purpurquinones A–C (1–3), purpuresters A and B (4 and 5), and 2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione (6), together with three known compounds, TAN-931 (7), (−)-mitorubrin (8), and orsellinic acid. The structures of 1–6 were elucidated primarily by NMR experiments. The absolute configurations of 1–4 were assigned on the basis of CD and NOESY data. Compounds 2–4 and 7 exhibited significant antiviral activity against H1N1, with IC50 values of 61.3, 64.0, 85.3, and 58.6 μM, respectively.