American Chemical Society
np5010196_si_001.pdf (15.62 MB)

Anti-inflammatory Terpenoids from the Leaves and Twigs of Dysoxylum gotadhora

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journal contribution
posted on 2015-05-22, 00:00 authored by Kan Jiang, Lu-Lin Chen, Shu-Fang Wang, Yi Wang, Ya Li, Kun Gao
Nine new terpenoids (13, 510), including three cyclolanostane triterpenoids (13) and six isopimarane diterpenoids (510), along with six known terpenoids (4, 1115), were isolated from the leaves and twigs of Dysoxylum gotadhora. Compound 1 represents a class of rare natural 21,24-epoxy cyclolanostane-type triterpenoids, and compounds 2 and 3 are the first examples of 21,25-epoxy cyclolanostane-type triterpenoids. Compounds 1, 2, 4, 8, and 15 exhibited noteworthy inhibition of nitric oxide production induced by lipopolysaccharide in RAW 264.7 cells with IC50 values of 25.5, 41.5, 27.4, 14.5, and 45.2 μM, respectively.