Anti-inflammatory Lanostane-Type Triterpene Acids from Piptoporus betulinus
journal contributionposted on 16.07.2003, 00:00 by Tsunashi Kamo, Masashi Asanoma, Hisao Shibata, Mitsuru Hirota
Six lanostane-type triterpene acids were isolated from the fruiting bodies of Piptoporus betulinus. They were identified as polyporenic acids A (1) and C (2), three derivatives of polyporenic acid A (3−5), and a novel compound, (+)-12α,28-dihydroxy-3α-(3‘-hydroxy-3‘-methylglutaryloxy)-24-methyllanosta-8,24(31)-dien-26-oic acid (6). All these compounds suppressed the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced edema on mouse ears by 49−86% with a 400 nmol/ear application.